Developing High-throughput 3D Cellular Models and Co-cultures
Previously Aired on April 25th, 2024
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Overview
This Bench Tips webinar will delve into how 3D cellular models can be generated and utilized to understand physiological pathways and minimize the use of animals for drug development. The speakers will describe their experiences designing 3D organoid models from animal and patient cells to accurately recapitulate the disease phenotype.
The advantages and limitations of different types of 3D cell models and co-cultures and applying them for specific applications like high-throughput drug screening will also be discussed.
You will learn about:
How to generate validated 3D models for replicating and studying disease pathways
Case studies highlighting generation of 3D models for inflammation, autoimmunity and cancer
Challenges with maintaining 3D cells for extended periods of time in culture
How to validate 3D models for a specific disease
Using 3D models to study immune modulation, transcriptomic changes, and drug responses
Researchers interested in the following should attend:
3D cellular models and assays
Cell-based assays
Cell and molecular biology
Assay development
Disease areas like inflammation, immunity, and cancer
Presenters
Ibrahim Sayed Ibrahim, Ph.D.
Research Assistant Professor, Department of Biomedical and Nutritional Science, University of Massachusetts-Lowell View Biography
Yi Wei Lim, Ph.D.
Postdoctoral Fellow, 3D Tissue Bioprinting, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health View Biography